Sedere SEDEX 100LT LT-ELSD Detector

Applications

The SEDEX 100LT is suitable for the detection and quantification of compounds that are less volatile than the mobile phase. Typical applications include:

High-Sensitivity Quantitative Analysis

• Trace impurities, low-level degradants, and challenging matrices requiring ultra-low noise and strong signal-to-noise performance.

Stability & Stress-Testing Studies

• Suitable for thermolabile or semi-volatile compounds that may be affected by high temperatures or ion-based detection techniques.

Complex Mixture Profiling

• Universal detection for samples containing a wide diversity of chemical structures, including lipids, carbohydrates, surfactants, polymers, peptides, natural products and excipients.

Pharmaceutical R&D and Quality Control

• Designed for validated analytical methods and regulated laboratory workflows, supported by GLP-friendly features and SOP documentation.

UHPLC & SFC High-Resolution Separations

• Fast chromatographic separations benefit from the detector’s rapid optical response and wide dynamic range.

When UV, RI or MS Detection Falls Short

• An effective solution for analytes lacking chromophores, poorly ionizable compounds, or compounds that are incompatible with mass spectrometry source conditions
  
   

Benefits

• Universal detection without chromophore requirements
• Low-temperature evaporation protects sensitive analytes
• Detects compounds not observable with UV or RI detectors
• Compatible with HPLC, UHPLC and SFC
• High sensitivity with typical sensitivity of 250 pg
• Broad dynamic range through SAGA™ automatic gain adjustment
• Excellent baseline stability and signal-to-noise performance
• Local operation or PC control
• Automatic remote shutdown reduces gas consumption and component wear
• Validation support through IQ/OQ/PQ documentation and SOPs
• Broad chromatography software compatibility
• Multiple nebulizer options for flow rates from 100 µL/min to 5 mL/min
  

Downloads

Sedere SEDEX100LT ELSD Detector Flyer

Frequently Asked Questions

What is the SEDEX 100LT?

The SEDEX 100LT is a Low-Temperature Evaporative Light Scattering Detector (LT-ELSD) for universal detection in HPLC, UHPLC and SFC applications.

Which compounds can be detected?

The SEDEX100LT detector measures compounds that are less volatile than the mobile phase, including carbohydrates, lipids, surfactants, polymers, peptides, natural products and pharmaceutical compounds

Does the detector require UV-active compounds?

No. The SEDEX 100LT does not require chromophores, fluorescence properties or electroactive groups for detection. 

Is the detector compatible with gradient methods?

Yes. The mobile phase is evaporated before detection, making LT-ELSD fully compatible with gradient chromatography and many commonly used buffers. 

Which chromatography techniques are supported?

The detector supports HPLC, UHPLC, µHPLC, HTLC, GPC/SEC, Flash Chromatography, CCC, SFC, and preparative LC workflows.

What is SAGA™?

SAGA™ (SEDEX Automated Gain Adjustment) automatically optimizes detector gain to prevent signal saturation and increase the dynamic range.