In cooperation with the Vrije Universiteit of Amsterdam Da Vinci Laboratory Solutions has developed the GC Fractionator: an application that automates the collection of micro fractions for a GC-MS analysis. Essential part of the application is the XYZ sampler combined with the Da Vinci smart grip.
Automated GC-Fractionation
Gas chromatography (GC) is a superior technique for separating many compounds. The fractionation of compounds from a GC analysis requires a complex setup and allows to collect only a limited number of fractions. Therefore a post-column fractionation after a liquid chromatography analysis is preferably used. The VU university of Amsterdam developed a new analytical technology for a highly efficient, high-resolution and high-yield fractionation of compounds after a GC separation. Da Vinci Laboratory Solutions engineered the dedicated hardware parts and also developed the software to automate the fractionation.
A robust, easy to operate and automated GC fractionation solution
Fractionation of complete chromatograms in a second scale resolution
Multiple injections for repeated fractionation in the same wells or vials allow for increased concentration of separated compounds
The combination of powerful GC separations with the sensitivity and selectivity of a bioassay/MS allows identification of bioactives by direct correlation
Parallel split to on-line chemical analysis makes it possible to correlate on-line chromatography with collected fractions for further off-line analysis
Post-column cell seeding approach makes a direct transfer to bioassays possible without the need for additional pipetting steps and dilutions
For environmental samples our GC fractionation in combination with endocrine disrupting cellular bioassays enables rapid, high resolution and straightforward Effect Directed Analysis (EDA)
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