DVLS DVLS GC Fractionator

In cooperation with the Vrije Universiteit of Amsterdam Da Vinci Laboratory Solutions has developed the GC Fractionator: an application that automates the collection of micro fractions for a GC-MS analysis. Essential part of the application is the XYZ sampler combined with the Da Vinci smart grip.


Automated GC-Fractionation

Gas chromatography (GC) is a superior technique for separating many compounds. The fractionation of compounds from a GC analysis requires a complex setup and allows to collect only a limited number of fractions. Therefore a post-column fractionation after a liquid chromatography analysis is preferably used. The VU university of Amsterdam developed a new analytical technology for a highly efficient, high-resolution and high-yield fractionation of compounds after a GC separation. Da Vinci Laboratory Solutions engineered the dedicated hardware parts and also developed the software to automate the fractionation.

  • Applications

    Post-column self seeding


  • Benefits

    • A robust, easy to operate and automated GC fractionation solution
    • Fractionation of complete chromatograms in a second scale resolution
    • Multiple injections for repeated fractionation in the same wells or vials allow for increased concentration of separated compounds
    • The combination of powerful GC separations with the sensitivity and selectivity of a bioassay/MS allows identification of bioactives by direct correlation
    • Parallel split to on-line chemical analysis makes it possible to correlate on-line chromatography with collected fractions for further off-line analysis
    • Post-column cell seeding approach makes a direct transfer to bioassays possible without the need for additional pipetting steps and dilutions
    • For environmental samples our GC fractionation in combination with endocrine disrupting cellular bioassays enables rapid, high resolution and straightforward Effect Directed Analysis (EDA)
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